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The development of mRNA-based CAR-Ts and DCs immunotherapies. (Right) CAR-T cell therapy has evolved by delivering mRNA-encoding antibody binding domain (CAR) to patient-isolated T-cells, which are then expressed, multiplied, and transferred back to the patient to recognize and destroy the malignant cells. (Left) DC vaccines have been developed by introducing mRNA-encoding TAAs into patient-isolated DCs, which are transferred to the patient after expression and <t>epitope</t> presentation for tumor recognition and triggering cytotoxic immune responses. Figure was made by Biorender.com .
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The development of mRNA-based CAR-Ts and DCs immunotherapies. (Right) CAR-T cell therapy has evolved by delivering mRNA-encoding antibody binding domain (CAR) to patient-isolated T-cells, which are then expressed, multiplied, and transferred back to the patient to recognize and destroy the malignant cells. (Left) DC vaccines have been developed by introducing mRNA-encoding TAAs into patient-isolated DCs, which are transferred to the patient after expression and epitope presentation for tumor recognition and triggering cytotoxic immune responses. Figure was made by Biorender.com .

Journal: Acta Pharmaceutica Sinica. B

Article Title: Advances and prospects of RNA delivery nanoplatforms for cancer therapy

doi: 10.1016/j.apsb.2024.09.009

Figure Lengend Snippet: The development of mRNA-based CAR-Ts and DCs immunotherapies. (Right) CAR-T cell therapy has evolved by delivering mRNA-encoding antibody binding domain (CAR) to patient-isolated T-cells, which are then expressed, multiplied, and transferred back to the patient to recognize and destroy the malignant cells. (Left) DC vaccines have been developed by introducing mRNA-encoding TAAs into patient-isolated DCs, which are transferred to the patient after expression and epitope presentation for tumor recognition and triggering cytotoxic immune responses. Figure was made by Biorender.com .

Article Snippet: An example of such a pipeline is the Real-time Epitope Computation for Oncology (RECON) pipeline developed by Neon Therapeutics, which predicts therapeutically relevant neoantigen targets.

Techniques: Binding Assay, Isolation, Vaccines, Expressing